Creamy, spicy, and irresistibly savory, Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce brings bold flavor to your dinner table in a comforting way. This dish layers blackened Cajun-seasoned chicken over tender penne pasta, all nestled in a velvety sauce enriched with garlic and real Parmesan. The contrast of smoky spice and creamy indulgence makes every bite dynamic.

This meal is the perfect blend of Southern flair and Italian comfort. It comes together in under 40 minutes, making it weeknight-friendly but impressive enough for guests. If you’re craving something cozy with a bit of heat, this pasta is bound to become a favorite.

Ingredients for this Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce

For the Chicken:

2 large chicken breasts, sliced
1 tablespoon olive oil
1 tablespoon Cajun seasoning (plus more for garnish)
Salt and pepper to taste

For the Pasta & Sauce:

8 oz penne pasta
2 tablespoons butter
4 cloves garlic, minced
1 tablespoon all-purpose flour
1 cup heavy cream
1/2 cup whole milk
1 cup freshly grated Parmesan cheese
1/2 teaspoon paprika
Salt and black pepper, to taste

Garnish:

Fresh parsley, chopped
Extra Parmesan for serving

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add the penne and cook until al dente according to package directions. Drain and set aside.

Step 2: Sear the Chicken

In a skillet, heat olive oil over medium-high heat. Toss chicken slices with Cajun seasoning, salt, and pepper. Sear the chicken in the hot pan until golden brown and cooked through, about 4-5 minutes per side. Remove and set aside.

Step 3: Make the Sauce Base

In the same skillet, reduce heat to medium and melt the butter. Add minced garlic and cook until fragrant, about 1 minute. Sprinkle flour and whisk to form a roux.

Step 4: Build the Cream Sauce

Slowly whisk in heavy cream and milk, letting the mixture thicken slightly. Stir in Parmesan cheese and paprika. Season with salt and pepper to taste. Let simmer for 3-4 minutes until creamy.

Step 5: Combine Pasta and Sauce

Add the cooked pasta to the sauce, stirring well to coat. Simmer for 2 minutes so the flavors meld.

Step 6: Assemble and Serve

Top the pasta with sliced Cajun chicken. Sprinkle with extra Parmesan and chopped parsley before serving.

Frequently Asked Questions

How spicy is Cajun Chicken Pasta?

The spice level depends on the Cajun seasoning used. You can always adjust by using less or adding extra cream to mellow the heat.

Can I use a different type of pasta?

Yes! Penne works well because it holds the sauce, but fettuccine, rotini, or even spaghetti can be used.

Can I substitute the heavy cream?

You can use half-and-half or full-fat coconut milk, but the sauce won’t be quite as rich.

What vegetables can I add?

Sautéed bell peppers, spinach, or mushrooms pair beautifully and add extra nutrition.

Is this gluten-free?

Not as written, but you can use gluten-free pasta and a GF flour blend for the roux.

Can I meal prep this?

Yes! Keep the chicken and pasta separate in the fridge for best results and combine them when ready to eat.